Article
The In Vitro Stability of Circulating Tumour DNA.
PloS one - 1 Jan 2016
Henao Diaz Emanuela, Yachnin Jeffrey, Grönberg Henrik, Lindberg Johan
Abstract excerpt
OBJECTIVE: DNA from apoptotic cancer cells, present in the circulation, has the potential to facilitate genomic profiling and disease monitoring. However, only low fractions of total cell-free DNA originates from cancer cells, limiting the applicability of circulating tumour DNA (ctDNA). Optimal sample processing is consequently of uttermost importance. Therefore, we evaluated the in vitro stability of ctDNA....
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