Article
Insights into psychosis risk from leukocyte microRNA expression.
Translational psychiatry - 13 Dec 2016
Jeffries C D, Perkins D O, Chandler S D, Stark T, Yeo E, Addington J, Bearden C E, Cadenhead K S, Cannon T D, Cornblatt B A, Mathalon D H, McGlashan T H, Seidman L J, Walker E F, Woods S W, Glatt S J, Tsuang M
Abstract excerpt
Dysregulation of immune system functions has been implicated in schizophrenia, suggesting that immune cells may be involved in the development of the disorder. With the goal of a biomarker assay for psychosis risk, we performed small RNA sequencing on RNA isolated from circulating immune cells. We compared baseline microRNA (miRNA) expression for persons who were unaffected (n=27) or who, over a subsequent 2-year...
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