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Article

A Maximum-Caliber Approach to Predicting Perturbed Folding Kinetics Due to Mutations.

Journal of chemical theory and computation - 13 Dec 2016

Wan Hongbin, Zhou Guangfeng, Voelz Vincent A

Abstract excerpt

We present a maximum-caliber method for inferring transition rates of a Markov state model (MSM) with perturbed equilibrium populations given estimates of state populations and rates for an unperturbed MSM. It is similar in spirit to previous approaches, but given the inclusion of prior information, it is more robust and simple to implement. We examine its performance in simple biased diffusion models of kinetics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27951664
DOI: 10.1021/acs.jctc.6b00938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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