Article
Early prediction of thiopurine-induced hepatotoxicity in inflammatory bowel disease.
Alimentary pharmacology & therapeutics - 1 Feb 2017
Wong D R, Coenen M J H, Derijks L J J, Vermeulen S H, van Marrewijk C J, Klungel O H, Scheffer H, Franke B, Guchelaar H-J, de Jong D J, Engels L G J B, Verbeek A L M, Hooymans P M
Abstract excerpt
BACKGROUND: Hepatotoxicity, gastrointestinal complaints and general malaise are common limiting adverse reactions of azathioprine and mercaptopurine in IBD patients, often related to high steady-state 6-methylmercaptopurine ribonucleotide (6-MMPR) metabolite concentrations. AIM: To determine the predictive value of 6-MMPR concentrations 1 week after treatment initiation (T1) for the development of these adverse...
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