Article
Environmental factors associated with familial or non-familial forms of Paget's disease of bone.
Joint bone spine - 1 Dec 2017
Audet Marie-Claude, Jean Sonia, Beaudoin Claudia, Guay-Bélanger Sabrina, Dumont Jeannette, Brown Jacques P, Michou Laëtitia
Abstract excerpt
OBJECTIVES: The most frequent mutation linked to Paget's disease of bone (PDB), p.Pro392Leu within SQSTM1 gene, leads to phenotypic characteristics of PDB, but this mutation is seemingly insufficient to result in complete pagetic osteoclast phenotype, suggesting that possible environmental factors play a role in PDB pathogenesis. We performed an exploratory study to identify environmental factors potentially...
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