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Article

Mathematical modeling of atopic dermatitis reveals "double-switch" mechanisms underlying 4 common disease phenotypes.

The Journal of allergy and clinical immunology - 1 Jun 2017

Domínguez-Hüttinger Elisa, Christodoulides Panayiotis, Miyauchi Kosuke, Irvine Alan D, Okada-Hatakeyama Mariko, Kubo Masato, Tanaka Reiko J

Abstract excerpt

BACKGROUND: The skin barrier acts as the first line of defense against constant exposure to biological, microbial, physical, and chemical environmental stressors. Dynamic interplay between defects in the skin barrier, dysfunctional immune responses, and environmental stressors are major factors in the development of atopic dermatitis (AD). A systems biology modeling approach can yield significant insights into...

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Identifiers

PMID: 27931974
DOI: 10.1016/j.jaci.2016.10.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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