The Mechanisms of Immunoglobulin E Sensitizations in Atopic Dermatitis.

Abstract excerpt

Atopic dermatitis (AD) is a chronic inflammatory skin disorder, which often precedes food allergy, asthma, and allergic rhinitis-a progression known as the atopic march. A key feature of AD is elevated allergen-specific immunoglobulin E (IgE), indicating sensitization to environmental, microbial, and self-antigens. This study examines the mechanisms driving IgE sensitization in AD, including epidermal barrier...

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