Article
Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of action on chitin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2016
Douris Vassilis, Steinbach Denise, Panteleri Rafaela, Livadaras Ioannis, Pickett John Anthony, Van Leeuwen Thomas, Nauen Ralf, Vontas John
Abstract excerpt
Despite the major role of chitin biosynthesis inhibitors such as benzoylureas (BPUs) in the control of pests in agricultural and public health for almost four decades, their molecular mode of action (MoA) has in most cases remained elusive. BPUs interfere with chitin biosynthesis and were thought to interact with sulfonylurea receptors that mediate chitin vesicle transport. Here, we uncover a mutation (I1042M) in...
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