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Asymmetric diamide resistance conferred by ryanodine receptor G4946E/V mutations in Plutella xylostella.

Pesticide biochemistry and physiology - 1 Aug 2026

Wang Xingliang, Jiang Dong, Hu Rui, Wu Shuwen, Shi Yu, Yang Yihua, Wu Yidong

Abstract excerpt

The diamondback moth, Plutella xylostella, has developed resistance to diamide insecticides, threatening global cruciferous crop production. Although convergent evolution of specific ryanodine receptor (RyR) mutations has been documented in various lepidopteran pests, functional validation within a uniform genetic background has been lacking for key agricultural species. Using CRISPR/Cas9, we generated homozygous...

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PMID: 42493011
DOI: 10.1016/j.pestbp.2026.107192

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