Article
The importance of genetic factors for the development of arthropathy: a longitudinal study of children and adolescents with haemophilia A.
Thrombosis and haemostasis - 26 Jan 2017
Gomperts Edward D, Schwarz John, Donfield Sharyne M, Lail Alice E, Astermark Jan, Hoots W Keith, Winkler Cheryl A, Berntorp Erik
Abstract excerpt
Haemophilia A is a congenital bleeding disorder characterised by recurrent haemorrhages into the major joints. Haemophilic arthropathy is a well-established outcome of recurrent joint bleeding; however, it is clear that multiple factors determine the extent and severity of its occurrence. We sought to identify genetic factors related to abnormalities in range of motion (ROM) in the knees, ankles and elbows in a...
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