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Article

Variability in clinical phenotype of severe haemophilia: the role of the first joint bleed.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Sept 2005

van Dijk K, Fischer K, van der Bom J G, Grobbee D E, van den Berg H M

Abstract excerpt

To quantify variation in clinical phenotype of severe haemophilia we performed a single centre cohort study among 171 severe haemophilia patients. Age at first joint bleed, treatment requirement (i.e. annual clotting factor use), annual bleeding frequency and arthropathy were documented. Because treatment strategies intensified during follow-up, patients were stratified in two age groups: patients born 1968-1985...

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Identifiers

PMID: 16128885
DOI: 10.1111/j.1365-2516.2005.01124.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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