Article
Subchronic perfluorooctanesulfonate (PFOS) exposure induces elevated mutant frequency in an in vivo λ transgenic medaka mutation assay.
Scientific reports - 8 Dec 2016
Chen Yuanhong, Hu Wei, Huang Changjiang, Hua Shushan, Wei Qihao, Bai Chenglian, Chen Jiangfei, Norris Michelle B, Winn Richard, Yang Dongren, Dong Qiaoxiang
Abstract excerpt
Perfluorooctanesulfonate (PFOS) has been widely detected in the environment, wildlife and humans, but few studies have ever examined its mutagenic effect in vivo. In the present study, we use a transgenic fish model, the λ transgenic medaka, to evaluate the potential mutagenicity of PFOS in vivo following a subchronic exposure of 30 days. The mutant frequency of cII target gene was 3.46 × 10-5 in liver tissue...
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