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Article

Histidine 375 Modulates CD4 Binding in HIV-1 CRF01_AE Envelope Glycoproteins.

Journal of virology - 15 Feb 2017

Zoubchenok Daria, Veillette Maxime, Prévost Jérémie, Sanders-Buell Eric, Wagh Kshitij, Korber Bette, Chenine Agnès L, Finzi Andrés

Abstract excerpt

The envelope glycoproteins (Envs) from human immunodeficiency virus type 1 (HIV-1) mediate viral entry. The binding of the HIV-1 gp120 glycoprotein to CD4 triggers conformational changes in gp120 that allow high-affinity binding to its coreceptors. In contrast to all other Envs from the same phylogenetic group, M, which possess a serine (S) at position 375, those from CRF01_AE strains possess a histidine (H) at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27928014
DOI: 10.1128/JVI.02151-16
PMCID: PMC5286895

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