Article
Obstacles to Translating Genotype-Phenotype Correlates in Metabolic Disease.
Physiology (Bethesda, Md.) - 1 Jan 2017
Sharma Anu, Vella Adrian
Abstract excerpt
Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.
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