Article
BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations.
Oncotarget - 19 Sept 2016
Cardona Andrés F, Rojas Leonardo, Wills Beatriz, Arrieta Oscar, Carranza Hernán, Vargas Carlos, Otero Jorge, Corrales-Rodriguez Luis, Martín Claudio, Reguart Noemí, Archila Pilar, Rodríguez July, Cuello Mauricio, Ortíz Carlos, Franco Sandra, Rolfo Christian, Rosell Rafael, on behalf of the CLICaP
Abstract excerpt
BACKGROUND: Germline alterations in the proapoptotic protein Bcl-2-like 11 (BIM) can have a crucial role in diverse tumors. To determine the clinical utility of detecting BIM deletion polymorphisms (par4226 bp/ par363 bp) in EGFR positive non-small-cell lung cancer (NSCLC) we examined the outcomes of patients with and without BIM alterations. RESULTS: BIM deletion was present in 14 patients (15.7%). There were no...
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