Lack of association between the BIM deletion polymorphism and the risk of lung cancer with and without EGFR mutations.

doi:10.1097/JTO.0000000000000371

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Article

Lack of association between the BIM deletion polymorphism and the risk of lung cancer with and without EGFR mutations.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2015

Ebi Hiromichi, Oze Isao, Nakagawa Takayuki, Ito Hidemi, Hosono Satoyo, Matsuda Fumihiko, Takahashi Meiko, Takeuchi Shinji, Sakao Yukinori, Hida Toyoaki, Faber Anthony C, Tanaka Hideo, Yatabe Yasushi, Mitsudomi Tetsuya, Yano Seiji, Matsuo Keitaro

Abstract excerpt

INTRODUCTION: The BIM deletion polymorphism in intron 2 was found in a significant percent of the Asian population. Patients with epidermal growth factor receptor (EGFR) mutant lung cancers harboring this BIM polymorphism have shorter progression free survival and overall response rates to EGFR tyrosine kinase inhibitors. However, the association between the BIM deletion polymorphism and lung cancer risk is...

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PMID: 25384174
DOI: 10.1097/JTO.0000000000000371

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