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Article

Efficacy of EGFR tyrosine kinase inhibitors in patients having EGFR-activating mutations with or without BIM polymorphisms.

Cancer chemotherapy and pharmacology - 1 Oct 2020

Ariyasu Ryo, Yanagitani Noriko, Tadokoro Kenichi, Yamaguchi Toshikazu, Uchibori Ken, Kitazono Satoru, Fujita Naoya, Katayama Ryohei, Nishio Makoto

Abstract excerpt

PURPOSE: Patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer with BIM deletion polymorphism may have a limited response to EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, some results of previous reports are discordant. It is necessary to evaluate the relationship between BIM polymorphism and the efficacy of EGFR-TKIs. METHODS: We retrospectively analyzed patients...

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PMID: 32948919
DOI: 10.1007/s00280-020-04136-7

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