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Article

Clinical implications of germline BCL2L11 deletion polymorphism in pretreated advanced NSCLC patients with osimertinib therapy.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2021

Li Xuanzong, Zhang Dai, Li Butuo, Zou Bing, Wang Shijiang, Fan Bingjie, Li Wanlong, Yu Jinming, Wang Linlin

Abstract excerpt

INTRODUCTION: B-cell lymphoma 2-like 11 (BCL-2-like 11, BCL2L11, also known as BIM) deletion polymorphism (BIM-del) has been associated with resistance to first-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), and is a poor prognostic factor for EGFR-mutant non-small-cell lung cancer (NSCLC) patients. Nevertheless, the impact of BIM-del in advanced NSCLC patients treated with...

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PMID: 33296806
DOI: 10.1016/j.lungcan.2020.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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