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Article

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers

6 Dec 2016

Abstract excerpt

Abstract Myc transcriptional activity is frequently deregulated in human cancers, but a Myc-driven gene signature with prognostic ability across multiple tumor types remains lacking. Here, we selected 18 Myc-regulated genes from published studies of Myc family targets in epithelial ovarian cancer (EOC) and neuroblastoma. A Myc family activity score derived from the 18 genes was correlated to MYC/MYCN/MYCL1...

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PMID: 27923830
DOI: 10.1158/0008-5472.can-15-2906

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