Article
Genomic study of the Type IVC secretion system in Clostridium difficile: understanding C. difficile evolution via horizontal gene transfer.
Genome - 1 Jan 2017
Zhang Wen, Cheng Ying, Du Pengcheng, Zhang Yuanyuan, Jia Hongbing, Li Xianping, Wang Jing, Han Na, Qiang Yujun, Chen Chen, Lu Jinxing
Abstract excerpt
Clostridium difficile, the etiological agent of Clostridium difficile infection (CDI), is a gram-positive, spore-forming bacillus that is responsible for ∼20% of antibiotic-related cases of diarrhea and nearly all cases of pseudomembranous colitis. Previous data have shown that a substantial proportion (11%) of the C. difficile genome consists of mobile genetic elements, including seven conjugative transposons....
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