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Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer.

Molecular cancer therapeutics - 1 Feb 2017

Kobayashi Yoshihisa, Azuma Koichi, Nagai Hiroki, Kim Young Hak, Togashi Yosuke, Sesumi Yuichi, Chiba Masato, Shimoji Masaki, Sato Katsuaki, Tomizawa Kenji, Takemoto Toshiki, Nishio Kazuto, Mitsudomi Tetsuya

Abstract excerpt

Lung cancers harboring common EGFR mutations respond to EGFR tyrosine kinase inhibitors (TKI). We previously reported that tumors with exon 18 mutations are particularly sensitive to irreversible second-generation (2G) afatinib compared with first-generation TKIs (1G-TKI). However, data on the mechanisms of acquired resistance to afatinib are limited. We established afatinib-resistant cells by transfecting Ba/F3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27913578
DOI: 10.1158/1535-7163.MCT-16-0407

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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