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Article

Inter-laboratory evolution of a model organism and its epistatic effects on mutagenesis screens.

Scientific reports - 1 Dec 2016

Bradley Michael D, Neu Devin, Bahar Fatmagul, Welch Roy D

Abstract excerpt

In theory, a few naturally occurring evolutionary changes in the genome of a model organism may have little or no observable impact on its wild type phenotype, and yet still substantially impact the phenotypes of mutant strains through epistasis. To see if this is happening in a model organism, we obtained nine different laboratories' wild type Myxococcus xanthus DK1622 "sublines" and sequenced each to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27905490
DOI: 10.1038/srep38001
PMCID: PMC5131308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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