Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource.

Abstract excerpt

Whole exome sequencing (WES) accelerates disease gene discovery using rare genetic variants, but further statistical and functional evidence is required to avoid false-discovery. To complement variant-driven disease gene discovery, here we present function-driven disease gene discovery in zebrafish (Danio rerio), a promising human disease model owing to its high anatomical and genomic similarity to humans. To...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Bayes Theorem