Article
A high-throughput approach to profile RNA structure.
Nucleic acids research - 17 Mar 2017
Delli Ponti Riccardo, Marti Stefanie, Armaos Alexandros, Tartaglia Gian Gaetano
Abstract excerpt
Here we introduce the Computational Recognition of Secondary Structure (CROSS) method to calculate the structural profile of an RNA sequence (single- or double-stranded state) at single-nucleotide resolution and without sequence length restrictions. We trained CROSS using data from high-throughput experiments such as Selective 2΄-Hydroxyl Acylation analyzed by Primer Extension (SHAPE; Mouse and HIV...
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