Article
Gene-metabolite network analysis in different nonalcoholic fatty liver disease phenotypes.
Experimental & molecular medicine - 13 Jan 2017
Liu Xiao-Lin, Ming Ya-Nan, Zhang Jing-Yi, Chen Xiao-Yu, Zeng Min-De, Mao Yi-Min
Abstract excerpt
We sought to identify common key regulators and build a gene-metabolite network in different nonalcoholic fatty liver disease (NAFLD) phenotypes. We used a high-fat diet (HFD), a methionine-choline-deficient diet (MCDD) and streptozocin (STZ) to establish nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH) and NAFL+type 2 diabetes mellitus (T2DM) in rat models, respectively. Transcriptomics and...
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