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Article

Loss of Cbl-PI3K interaction modulates the periosteal response to fracture by enhancing osteogenic commitment and differentiation.

Bone - 1 Feb 2017

Scanlon Vanessa, Walia Bhavita, Yu Jungeun, Hansen Marc, Drissi Hicham, Maye Peter, Sanjay Archana

Abstract excerpt

The periosteum contains multipotent skeletal progenitors that contribute to bone repair. The signaling pathways regulating the response of periosteal cells to fracture are largely unknown. Phosphatidylinositol-3 Kinase (PI3K), a prominent lipid kinase, is a major signaling protein downstream of several factors that regulate osteoblast differentiation. Cbl is an E3 ubiquitin ligase and a major adaptor protein that...

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Source

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Identifiers

PMID: 27884787
DOI: 10.1016/j.bone.2016.11.020
PMCID: PMC5819877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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