Article
RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.
Clinical and experimental immunology - 1 Apr 2017
Kluger M A, Nosko A, Ramcke T, Goerke B, Meyer M C, Wegscheid C, Luig M, Tiegs G, Stahl R A K, Steinmetz O M
Abstract excerpt
Systemic lupus erythematosus (SLE) is a common autoimmune disorder with a complex and poorly understood immunopathogenesis. However, a pathogenic role for the T helper type 17 (Th17) axis was demonstrated by many studies, while regulatory T cells (Tregs ) were shown to mediate protection. Recently, we and others characterized a novel and independent T cell population expressing both the Treg characteristic...
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