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Autophagy controls centrosome number by degrading Cep63

21 Nov 2016

Abstract excerpt

Abstract Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin–proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63...

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Share to Autophagy in Disease and Therapy
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PMID: 27869116
DOI: 10.1038/ncomms13508

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