Article
Long non-coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia-reperfusion injury.
Cell biology international - 1 Jan 2017
Zhao Zhi-Hui, Hao Wei, Meng Qing-Tao, Du Xiao-Bing, Lei Shao-Qing, Xia Zhong-Yuan
Abstract excerpt
Long non-coding (lncRNA) MALAT1 can be increased by hypoxia or ischemic limbs. Also, downregulation of MALAT1 contributes to reduction of cardiomyocyte apoptosis. However, the functional involvement of MALAT1 in myocardial ischemia-reperfusion (I/R) injury has not been defined. This study investigated the functional involvement of lncRNA-MALAT1 in cardioprotective effects of fentanyl. HL-1, a cardiac muscle cell...
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