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Article

Gadd45 is a novel mediator of cardiomyocyte apoptosis induced by ischaemia/hypoxia

12 Feb 2010

Abstract excerpt

AIMS: Because apoptotic death plays a critical role in cardiomyocyte loss during ischaemic heart injury, a detailed understanding of the mechanisms involved is likely to have a substantial impact on the optimization and development of treatment strategies. The goal of this study was to assess gene profiling during ischaemia/hypoxia and to evaluate the functions of ischaemia/hypoxia-responsive genes in in vivo and...

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Share to Cardiac Ischemia and Reperfusion
Share to Cell death mechanisms and regulation
Share to Mitochondrial Function and Pathology

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PMID: 20154065
DOI: 10.1093/cvr/cvq048

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