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Article

Epipolymorphisms associated with the clinical outcome of autoimmune arthritis affect CD4 + T cell activation pathways

14 Nov 2016

Abstract excerpt

T-cell DNA methylome of 68 poly-articular and extended oligo-articular JIA patients, before and after anti-TNF therapy withdrawal, to identify features associated with maintenance of inactive disease. Individual CpG sites were clustered in coherent modules without a priori knowledge of their function through network analysis. The methylation level of several CpG modules, specifically those enriched in CpG sites...

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PMID: 27849614
DOI: 10.1073/pnas.1524056113

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