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Article

The TYMS-TSER polymorphism is associated with toxicity of low-dose capecitabine in patients with advanced gastrointestinal cancer.

Anti-cancer drugs - 1 Nov 2016

Romiti Adriana, Roberto Michela, D'Antonio Chiara, Onesti Concetta E, Barucca Viola, Milano Annalisa, Gentile Giovanna, Lionetto Luana, Medda Emanuela, Mazzuca Federica, Botticelli Andrea, Falcone Rosa, Simmaco Maurizio, Marchetti Paolo

Abstract excerpt

Low doses of drugs delivered at close, regular intervals are increasingly being used to manage patients with different neoplasms. Despite the good tolerability, treatment-related adverse events still occur following metronomic protocols. The aim of this study was to retrospectively investigate whether polymorphisms of different genes involved in fluoropyrimidine metabolism and 5-fluorouracil (5-FU) degradation...

Read the complete abstract on PubMed

Topics

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Share to Capecitabine
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Gastrointestinal Neoplasms

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Thymidylate Synthase

Source

Identifiers

PMID: 27557140
DOI: 10.1097/CAD.0000000000000429

Genes

DPYD
MTHFR
TYMS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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