Article
Specific micro-RNA expression patterns distinguish the basal and luminal subtypes of muscle-invasive bladder cancer.
Oncotarget - 6 Dec 2016
Ochoa Andrea E, Choi Woonyoung, Su Xiaoping, Siefker-Radtke Arlene, Czerniak Bogdan, Dinney Colin, McConkey David J
Abstract excerpt
The roles of non-coding RNAs in controlling clinical and biological heterogeneity in bladder cancer remain unclear. We used TCGA's published dataset (n = 405 tumors) as a discovery cohort and created a new validation cohort to define the miRNA expression patterns in the basal and luminal molecular subtypes of muscle-invasive bladder cancer (MIBC). We identified 63 miRNAs by PAM, which optimally identified basal...
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