Article
SNCA mutation p.Ala53Glu is derived from a common founder in the Finnish population.
Neurobiology of aging - 1 Feb 2017
Pasanen Petra, Palin Eino, Pohjolan-Pirhonen Risto, Pöyhönen Minna, Rinne Juha O, Päivärinta Markku, Martikainen Mika H, Kaasinen Valtteri, Hietala Marja, Gardberg Maria, Saukkonen Anna Maija, Eerola-Rautio Johanna, Kaakkola Seppo, Lyytinen Jukka, Tienari Pentti J, Paetau Anders, Suomalainen Anu, Myllykangas Liisa
Abstract excerpt
Mutations in SNCA are rare causes of familial Parkinson's disease (PD). We have previously described a novel p.Ala53Glu mutation in 2 Finnish families. To assess this mutation's frequency among Finnish PD patients, we screened 110 PD patients (mean age-of-onset 60 years) from Western Finland by Sanger sequencing of the third coding exon of SNCA. In addition, a sample of 47 PD subjects (mean age-of-onset 53 years)...
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