Article
Hippocampus-specific deficiency of IL-15Rα contributes to greater anxiety-like behaviors in mice.
Metabolic brain disease - 1 Apr 2017
Nguyen Linda, Bohlen Joseph, Stricker Janelle, Chahal Ikttesh, Zhang Hanting, Pistilli Emidio E
Abstract excerpt
A hippocampus-specific IL15RαKO mouse (hipIl15ra fl/fl /Cre+) was generated to test the hypothesis that the targeted deletion of interleukin-15 receptor alpha (IL-15Rα) in the hippocampus contributes to altered behavior, including greater levels of anxiety and ambulatory activity. Using Cre-loxP, exons 2 and 3 of the IL-15Rα gene were excised within the hippocampus, while normal expression was maintained within...
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