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Article

AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1

3 Dec 2020

Abstract excerpt

Colorectal cancer (CRC) is a common malignant tumor and is one of the leading causes of cancer-related deaths worldwide. Absent in melanoma 2 (AIM2), as a member of the pyrin-HIN family proteins, plays contentious roles in different types of cancers. In the present work, we provide evidence that AIM2 was commonly downregulated in human CRC and loss of AIM2 significantly correlated with tumor size, depth of...

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PMID: 33291082
DOI: 10.18632/aging.202226

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