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Article

Angiogenesis-Related Functions of Wnt Signaling in Colorectal Carcinogenesis

2 Dec 2020

Abstract excerpt

Aberrant activation of the Wnt/Fzd/β-catenin signaling pathway is one of the major molecular mechanisms of colorectal cancer (CRC) development and progression. On the other hand, one of the most common clinical CRC characteristics include high levels of angiogenesis, which is a key event in cancer cell dissemination and distant metastasis. The canonical Wnt/β-catenin downstream signaling regulates the most...

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PMID: 33276489
DOI: 10.3390/cancers12123601

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