Article
A functional variant rs4442975 modulating FOXA1-binding affinity does not influence the risk or progression of breast cancer in Chinese Han population.
Oncotarget - 6 Dec 2016
Zhang Yi, Li Yan, Jiang Shaojie, Chen Wei, Lou Jiao, Ke Juntao, Li Jiaoyuan, Zhu Ying, Gong Yajie, Yang Yang, Tian Jianbo, Peng Xiating, Zou Danyi, Gong Jing, Chang Jiang, Miao Xiaoping, Zhong Rong
Abstract excerpt
The DNA-binding protein FOXA1 has been shown to regulate nearly all estrogen receptor-chromatin interactions, thereby influencing target gene expression levels in breast cancer (BC) cells. Recently, the rs4442975 T-allele, which disrupts the recruitment of FOXA1 and interacts with the IGFBP5 promoter, was associated to BC susceptibility in a European population. We conducted a hospital-based case-control study...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.