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Article

MicroRNAs in neuroblastoma tumorigenesis, therapy resistance, and disease evolution

1 Jan 2019

Abstract excerpt

Neuroblastoma (NB) deriving from neural crest cells is the most common extra-cranial solid cancer at infancy. NB originates within the peripheral sympathetic ganglia in adrenal medulla and along the midline of the body. Clinically, NB exhibits significant heterogeneity stretching from spontaneous regression to rapid progression to therapy resistance. MicroRNAs (miRNAs, miRs) are small (19-22 nt in length)...

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PMID: 31867575
DOI: 10.20517/cdr.2019.68

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