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Article

Primary Angle Closure and Sequence Variants within MicroRNA Binding Sites of Genes Involved in Eye Development.

PloS one - 1 Jan 2016

Shi Haihong, Zhang Junfang, Zhu Rongrong, Hu Nan, Lu Hong, Yang Mei, Qin Bai, Shi Jian, Guan Huaijin

Abstract excerpt

PURPOSE: The formation of primary angle closure (PAC) and primary angle closure glaucoma (PACG) is regulated by a tissue remodeling pathway that plays a critical role in eye development. MicroRNAs (miRNAs) are powerful gene expression regulators and may exert their effects on tissue remodeling genes. This study investigated the associations between gene variants (single-nucleotide polymorphism, SNP) in miRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27824919
DOI: 10.1371/journal.pone.0166055
PMCID: PMC5100968

Genes

MTHFR
PCMTD1
ZNRF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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