Mitochondria in the pathophysiology of Alzheimer's and Parkinson's diseases.

doi:10.2741/4521

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Article

Mitochondria in the pathophysiology of Alzheimer's and Parkinson's diseases.

Frontiers in bioscience (Landmark edition) - 1 Jan 2017

Onyango Isaac G, Khan Shaharyar M, Bennett James P

Abstract excerpt

Mitochondria are responsible for the majority of energy production in energy-intensive tissues like brain, modulate Ca+2 signaling and control initiation of cell death. Because of their extensive use of oxygen and lack of protective histone proteins, mitochondria are vulnerable to oxidative stress (ROS)-induced damage to their genome (mtDNA), respiratory chain proteins and ROS repair enzymes. Animal and cell...

Topics

Alzheimer Disease
Animals
Brain
Calcium
DNA, Mitochondrial
Humans
Inflammation
Mitochondria
Mitophagy
Mutation
Organelle Biogenesis
Oxidative Stress
Parkinson Disease
Reactive Oxygen Species
Signal Transduction

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Open in PubMed

Identifiers

PMID: 27814651
DOI: 10.2741/4521

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