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Article

Mitochondria in the pathophysiology of Alzheimer's and Parkinson's diseases.

Frontiers in bioscience (Landmark edition) - 1 Jan 2017

Onyango Isaac G, Khan Shaharyar M, Bennett James P

Abstract excerpt

Mitochondria are responsible for the majority of energy production in energy-intensive tissues like brain, modulate Ca+2 signaling and control initiation of cell death. Because of their extensive use of oxygen and lack of protective histone proteins, mitochondria are vulnerable to oxidative stress (ROS)-induced damage to their genome (mtDNA), respiratory chain proteins and ROS repair enzymes. Animal and cell...

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Identifiers

PMID: 27814651
DOI: 10.2741/4521

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PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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