Article
MicroRNAs in Human Cerebrospinal Fluid as Biomarkers for Alzheimer's Disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2017
Lusardi Theresa A, Phillips Jay I, Wiedrick Jack T, Harrington Christina A, Lind Babett, Lapidus Jodi A, Quinn Joseph F, Saugstad Julie A
Abstract excerpt
BACKGROUND: Currently available biomarkers of Alzheimer's disease (AD) include cerebrospinal fluid (CSF) protein analysis and amyloid PET imaging, each of which has limitations. The discovery of extracellular microRNAs (miRNAs) in CSF raises the possibility that miRNA may serve as novel biomarkers of AD. OBJECTIVE: Investigate miRNAs in CSF obtained from living donors as biomarkers for AD. METHODS: We profiled...
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