Prevalence of alpha-1 antitrypsin deficiency and allele frequency in patients with COPD in Brazil.

doi:10.1590/S1806-37562015000000180

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Article

Prevalence of alpha-1 antitrypsin deficiency and allele frequency in patients with COPD in Brazil.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia - 1 Jan 2000

Russo Rodrigo, Zillmer Laura Russo, Nascimento Oliver Augusto, Manzano Beatriz, Ivanaga Ivan Teruaki, Fritscher Leandro, Lundgren Fernando, Miravitlles Marc, Gondim Heicilainy Del Carlos, Santos Gildo, Alves Marcela Amorim, Oliveira Maria Vera, Souza Altay Alves Lino de, Sales Maria Penha Uchoa, Jardim José Roberto

Abstract excerpt

OBJECTIVE:: To determine the prevalence of alpha 1-antitrypsin (AAT) deficiency (AATD), as well as allele frequency, in COPD patients in Brazil. METHODS:: This was a cross-sectional study involving 926 COPD patients 40 years of age or older, from five Brazilian states. All patients underwent determination of AAT levels in dried blood spot (DBS) samples by nephelometry. Those with DBS AAT levels ≤ 2.64 mg/dL...

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PMID: 27812629
DOI: 10.1590/S1806-37562015000000180
PMCID: PMC5094866

Genes

SERPINA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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