Article
Indications for active case searches and intravenous alpha-1 antitrypsin treatment for patients with alpha-1 antitrypsin deficiency chronic pulmonary obstructive disease: an update.
Archivos de bronconeumologia - 1 Apr 2015
Casas Francisco, Blanco Ignacio, Martínez María Teresa, Bustamante Ana, Miravitlles Marc, Cadenas Sergio, Hernández José M, Lázaro Lourdes, Rodríguez Esther, Rodríguez-Frías Francisco, Torres María, Lara Beatriz
Abstract excerpt
The effect of hereditary alpha-1 antitrypsin (AAT) deficiency can manifest clinically in the form of chronic obstructive pulmonary disease (COPD). AAT deficiency (AATD) is defined as a serum concentration lower than 35% of the expected mean value or 50 mg/dl (determined by nephelometry). It is associated in over 95% of cases with Pi*ZZ genotypes, and much less frequently with other genotypes resulting from...
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