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Article

Leveraging genetically simple traits to identify small-effect variants for complex phenotypes.

BMC genomics - 3 Nov 2016

Kemper K E, Littlejohn M D, Lopdell T, Hayes B J, Bennett L E, Williams R P, Xu X Q, Visscher P M, Carrick M J, Goddard M E

Abstract excerpt

BACKGROUND: Polymorphisms underlying complex traits often explain a small part (less than 1 %) of the phenotypic variance (σ2P). This makes identification of mutations underling complex traits difficult and usually only a subset of large-effect loci are identified. One approach to identify more loci is to increase sample size of experiments but here we propose an alternative. The aim of this paper is to use...

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PMID: 27809761
DOI: 10.1186/s12864-016-3175-3
PMCID: PMC5094043

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