Article
A key gene modulating oxytocin efficacy in autism: genome-wide discovery and verification in randomized controlled trials datasets.
Molecular psychiatry - 1 Aug 2026
Kuwabara Hitoshi, Kojima Masaki, Benner Seico, Otowa Takeshi, Watanabe Takamitsu, Kuroda Miho, Owada Keiho, Yassin Walid, Hamada Junko, Kano Yukiko, Uno Yota, Kushima Itaru, Mori Daisuke, Arioka Yuko, Munesue Toshio, Kasai Kiyoto, Higashida Haruhiro, Abe Osamu, Takao Hidemasa, Wakuda Tomoyasu, Kameno Yosuke, Inoue Jun, Harada Taeko, Yamauchi Aya, Ogawa Nanayo, Honda Nami, Kikuchi Saya, Seto Moe, Tomita Hiroaki, Miyoshi Noriko, Matsumoto Megumi, Kawaguchi Yuko, Kanai Koji, Ikeda Manabu, Nakamura Itta, Isomura Shuichi, Hirano Yoji, Onitsuka Toshiaki, Takahashi Nagahide, Nakashima Mitsuko, Saitsu Hirotomo, Kondo Kenji, Ikeda Masashi, Iwata Nakao, Shimada Mihoko, Sasaki Tsukasa, Takei Nori, Ozaki Norio, Kosaka Hirotaka, Okada Takashi, Yamasue Hidenori
Abstract excerpt
Previous studies suggest that oxytocin has therapeutic potential for modulating core symptoms of autism spectrum disorder (ASD), although findings have been inconsistent. The unknown mechanisms underlying oxytocin's effects and the substantial individual variability in treatment response impede the development of effective oxytocin-based therapies. In this study, we conducted a genome-wide association study...
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