Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development

Abstract excerpt

Klebsiella pneumoniae ( Kp ) has become the most important bacterial pathogen causing high mortality rates in clinical patients due to the continuous evolution to several important variants such as carbapenem-resistant (CR- Kp ), hypervirulent (hv Kp ) and both CR and hv K. pneumoniae (CR-hv Kp ). The high mortality caused by clinical hv Kp is attributed to the non-response to antibiotic treatment. Therefore, a...

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