Communicating BRCA research results to patients enrolled in international clinical trials: lessons learnt from the AGO-OVAR 16 study.

doi:10.1186/s12910-016-0144-y

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Communicating BRCA research results to patients enrolled in international clinical trials: lessons learnt from the AGO-OVAR 16 study.

BMC medical ethics - 21 Oct 2016

Pulford David J, Harter Philipp, Floquet Anne, Barrett Catherine, Suh Dong Hoon, Friedlander Michael, Arranz José Angel, Hasegawa Kosei, Tada Hiroomi, Vuylsteke Peter, Mirza Mansoor R, Donadello Nicoletta, Scambia Giovanni, Johnson Toby, Cox Charles, Chan John K, Imhof Martin, Herzog Thomas J, Calvert Paula, Wimberger Pauline, Berton-Rigaud Dominique, Lim Myong Cheol, Elser Gabriele, Xu Chun-Fang, du Bois Andreas

Abstract excerpt

BACKGROUND: The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicating relevant genetic research results to individual patients. METHODS: An exploratory pharmacogenetic analysis was conducted in the international ovarian cancer phase III trial, AGO-OVAR 16, which...

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PMID: 27769273
DOI: 10.1186/s12910-016-0144-y
PMCID: PMC5073453

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BRCA1

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