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Article

A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline.

American journal of respiratory and critical care medicine - 15 May 2017

Wei Yongyue, Tejera Paula, Wang Zhaoxi, Zhang Ruyang, Chen Feng, Su Li, Lin Xihong, Bajwa Ednan K, Thompson B Taylor, Christiani David C

Abstract excerpt

RATIONALE: Platelets are believed to contribute to acute respiratory distress syndrome (ARDS) pathogenesis through inflammatory coagulation pathways. We recently reported that leucine-rich repeat-containing 16A (LRRC16A) modulates baseline platelet counts to mediate ARDS risk. OBJECTIVES: To examine the role of LRRC16A in ARDS survival and its mediating effect through platelets. METHODS: A total of 414 cases with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27768389
DOI: 10.1164/rccm.201605-0946OC
PMCID: PMC5443896

Genes

CARMIL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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