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Clinical subtypes and genetic heterogeneity: of lumping and splitting in Parkinson disease.

Current opinion in neurology - 1 Dec 2016

von Coelln Rainer, Shulman Lisa M

Abstract excerpt

PURPOSE OF REVIEW: Recent studies on clinical, genetic and pathological heterogeneity of Parkinson disease have renewed the old debate whether we should think of Parkinson disease as one disease with variations, or as a group of independent diseases that happen to present with similar phenotypes. Here, we provide an overview of where the debate is coming from, and how recent findings in clinical subtyping,...

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PMID: 27749396
DOI: 10.1097/WCO.0000000000000384

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